Amitriptyline (Elavil)

Amitriptyline (Elavil)
Uses: :
Neuropathic pain
Depression
Insomnia
Postherpetic Neuralgia
Migraine prophylaxis
Eating disorder

Pointers:
effective in 3 weeks
sleep / appetite precedes analgesic effects
half life 9-27 hrs; metabolized by hepatic, renally excr 18%, small amounts excreted in feces
avoid in elderly due to side effects

Side effects:
constipation, drowsiness, dry mouth, confusion, inc sleep, inc appetite. QT prolongation, hypotension,

Available:
available:Tab 10, 25, 50, 75, 100, 150 mg. Oral Sol 25 mg/5 ml; 50 mg /5 ml
Rx
10-25 mg hs; 100-300 mg po / d as hs


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