Neuroleptic malignant syndrome

Neuroleptic Malignant Syndrome = Mute + Rigid

NMS: Neuroleptic Malignant Syndrome: > 3-9 d of high potency antipsychotic, S/S :  Hyperthermia, encephalopathy, rigidity. Autonomic instability. Dysphagia, incontinent. Inc CK, proteinuria, myoglobinuria, hypocalcemia, hypomagnesemia, hypophosphatemia. Normal imaging & CSF. EEG : Diffuse slowing. Rx: Bromocriptine 2.5 -10 mg po qid. Dantrolene Na 3-5 mg/kg IV tid, switch to 1 mg/kg po q 6 hrs. Amantadine, Levodopa / Carb, rx for Catatonia ECT.


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