Nurtec ODT Rimegepant Migraine

🟢 Migraine

🟢 Nurtec 75 mg ODT /d for ACUTE attack

🟢 Nurtec 75 mg QOD for prophylaxis

🟢 CGRP inhibitor : blocks calcitonin gene-related peptide

🟢 HL 11 hrs

🟢 SE: Nausea, dyspepsia, GI pain, rash, dyspnea,

🟢 hypersensitive reaction : delayed /immediate

🟢 No pregnancy / no lactation data available

🟢 CYP3A4 inhibitors : ↑Rimegepant level so avoid any more Rimegepant within 48 hrs

CYP3A4 inhibitors: HIV meds : Ritonavir, Clarithromycin,

🟢 CYP3A INDUCERS : ↓ Rimegepant

CYP3A inducers: Phenytoin, Rifampin,

🟢 BCRP chemo / P-gp inhibitors : ↑ Rimegepant level

🛑 P-gp inhibitors: Efflux pump in the small intestine ↑ absorption of meds. Digoxin, Verapamil, Nifedipine, Dexamethasone, Amiodarone, Carvedilol, Amiodarone, Azole anti-fungal, Erythromycin, Tamoxifen, chlorpromazine, Quinidine

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