Optic neuritis

Optic neuritis

ON : Optic Neuritis
20-50 yrs, 75% F, 85% white, ๐Ÿ‘‰๐ŸฟMovement induce painful unilateral central visual loss, abn color discrimination over days. + Uhthoff phenomenon. afferent pupillary defect, Marcus Gun pupil. ๐Ÿ‘‰๐ŸฟCentrocecal scotomas: optic neuritis.
๐Ÿ‘‰๐ŸฟW/U: ESR, TFT, ANA, ACE, RPR, DNA mutation study, VEP, MRI : 40%> I lesion, abnormal optic n MRI. ๐Ÿ‘‰๐ŸฟRx: Methyprednisolone: 250 mg iv q6urs, x3d, then prednisone img/kg . po qd x11 d, then taper over 4d,may delay MS and hasten recovery. ๐Ÿ‘‰๐Ÿฟ 95% better in 5 m, 28% recurrance in 5m, 30% develop MS in 5 Yrs. ๐Ÿ‘‰๐Ÿฟ24 patients given ACTHAR 80 units for five days followed by 40 units for 10 days. 

https://actharhcp.com/clinical-experience/optic-neuritis/sergott/#tab2

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