Prognosticating Multiple sclerosis

Prognosis of Multiple sclerosis


👉 Older age at onset 👉 Male👉Low VIT D👉Smoking👉Multiple comorbidities👉Higher number & volume of T-2 lesions👉Brain atrophy👉Gadolinium enhancing lesions👉 RRMS entering in to chronic progressive form 👉 T 1 hypodense lesions signifies cognitive decline.👉 In primary progressive MS which causes grey matter brain volume loss signifies clinical & cognitive decline👉PRISMS study : higher MAGNIMS score is associated with EDSS progression & increase clinical disease activity.👉 Serum neurofilament light sNfL elevation in patients with new clinical symptoms and enhancing periventricular lesions👉 Oligoclonal bands in CSF 👉higher level of chitinase 3 in CSF ( MS/CIS clinically isolated synd)👉 presence of T1 hyperintense lesions causes cognitive decline👉 higher relapse rate👉 Brain stem, cerebellar, spinal cord lesions at onset👉 Thining of Retinal nerve fiber detected optical coherence tomography

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