Axial FLAIR (a, b & c) and T2 weighted (d) Brain MRI from patients with CADASIL. The exams in 2a and 2b are from asymptomatic patients with depression. Note temporal lobe lesions even in asymptomatic patients (2b). In Figure 2a and d periventricular diffuse white matter ischemic lesion and multiple lacunar lesions in thalamus, pons / basal ganglia