Toxoplasmosis

Toxoplasmosis
S/S: Mild s/s in healthy adults, mild flu like s/s, swollen lymph nodes, during pregnancy: congenital toxoplasmosis. Headache, confusion, seizures hemiparesis, CN + brainstem involvement, hemiparesis, focal neurological symptoms, CD 4 count < 100 cells / mic L in people with AIDS. IISpread: poorly cooked food containing a spores, infested cat feces, infected mother & blood transfusion. 
Imaging: MRI: show Ring enhancing lesions in the white matter , basal ganglia, corticomedullary junction. Labs: + antibodies in serology amniotic fluid or positive CSF polymerase chain reaction. 

Rx : 👉🏿 Wash hands and wear gloves if you clean the cat litter👉🏿6 weeks or therapy of triple antibiotics: Pyrimethamine (Daraprim) 100-200 mg for 2 days and then 75 to 100 mg /d+Sulfasalazine (Microsufom) 1.5 to 2 g PO QID +Folinic acid (Wellcovrin) 10-50 mg/d
Discuss w infectious disease for new guidelines. 

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