Ubrogepant (Ubrelvy)

Ubrogepant (Ubrelvy) for acute migraine attack.
CGRP inhibitors 👉🏿Tab 50 mg, 100 mg👉🏿 50-100 mg po x1 repeat after 2 hrs 👉🏿Max dose 200 mg/d
🙅🏼CI: allergy to med, crcl<15, CYP3A4 inhibitors, such as ketoconazole, clarithromycin, itraconazole.👉🏿Caution: cr cl 15-29 hep child -Pugh class c : max 50 mg /dose👉🏿 No lab monitoring 👉🏿 Side effects: nausea 4%,  sleepiness 3%, dry mouth 2%🚦Pregnancy & Lactation :no human data available⏳ Half life: 5 – 7 h🔀 excretion: primarily by GI/feces 👉🏿Metabolism: CYP 450, 3A4 substrate, unknown


Public:    https://www.ubrelvy.com/search?search=Tablet

Professionals : https://www.ubrelvyhcp.com/


Low dose is better with the following:Grape fruit juiceverapamilphenytoin
cyclosporine ciprofloxacinfluconazolefluvoxamine barbiturates rifampin St. John’s Wort quinidine, carvedilol, eltrombopag, curcum

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1 thought on “Ubrogepant (Ubrelvy)”

  1. Somebody expended on this.

    👉🏽Peak plasma concentration: 1.5hr
    👉🏽Time to reach active concentration: 9-11 minutes

    Dosing :

    👉🏽Ubrelvy should not be used with strong CYP3A4 inducers (phenytoin, barbiturates, rifampin, St. John’s Wort) that increase the metabolism of Ubrogepant, decreasing its exposure.

    👉🏽 Dosing of ubrogepant should be adjusted when used with moderate or weak CYP3A4 inducers to higher dose.

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